Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MRTX9768
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Purity: 98.0%
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2629314-68-5

2629314-68-5 structure

2629314-68-5 structure

Name: MRTX9768
Chemical Name: MRTX9768
CAS Number: 2629314-68-5
Molecular Formula: C₂₄H₁₇FN₆O
Molecular Weight: 424.43
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2021-09-11 09:27:09
Modify Date: 2025-08-25 10:09:51
MRTX9768 is a potent, orally active PRMT5 inhibitor. MRTX9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors[1].

Name	MRTX9768

Description	MRTX9768 is a potent, orally active PRMT5 inhibitor. MRTX9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	PRMT5[1]
In Vitro	MRTX9768 inhibits SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM)[1].
In Vivo	In xenograft studies, oral administration of MRTX9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors[1].
References	[1]. Christopher R. et al. Fragment based discovery of MRTX9768, a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr LB003.

Molecular Formula	C₂₄H₁₇FN₆O
Molecular Weight	424.43

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