CGS 35066

Modify Date: 2025-09-12 15:45:32

CGS 35066 Structure
CGS 35066 structure
Common Name CGS 35066
CAS Number 261619-50-5 Molecular Weight 349.27500
Density N/A Boiling Point N/A
Molecular Formula C16H16NO6P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CGS 35066


CGS35066 is a potent and selective aminophosphonate inhibitor of endothelin-converting enzyme-1 (ECE-1). CGS 35066 inhibits the activity of human ECE-1 and rat kidney neutral endopeptidase 24.11 (NEP) in vitro with IC50 values of 22 nM and 2.3 μM, respectively[1].

 Names

Name CGS 35066,α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoicacid
Synonym More Synonyms

 CGS 35066 Biological Activity

Description CGS35066 is a potent and selective aminophosphonate inhibitor of endothelin-converting enzyme-1 (ECE-1). CGS 35066 inhibits the activity of human ECE-1 and rat kidney neutral endopeptidase 24.11 (NEP) in vitro with IC50 values of 22 nM and 2.3 μM, respectively[1].
Related Catalog
References

[1]. A J Trapani, et al. Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S40-3.  

 Chemical & Physical Properties

Molecular Formula C16H16NO6P
Molecular Weight 349.27500
Exact Mass 349.07200
PSA 129.81000
LogP 2.69740

 Synonyms

Gisadenafil besylate
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