CGS 35066

Names

[ Name ]:
CGS 35066

[Synonym ]:
Gisadenafil besylate

Biological Activity

[Description]:

CGS35066 is a potent and selective aminophosphonate inhibitor of endothelin-converting enzyme-1 (ECE-1). CGS 35066 inhibits the activity of human ECE-1 and rat kidney neutral endopeptidase 24.11 (NEP) in vitro with IC50 values of 22 nM and 2.3 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. A J Trapani, et al. Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S40-3.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₆NO₆P

[ Molecular Weight ]:
349.27500

[ Exact Mass ]:
349.07200

[ PSA ]:
129.81000

[ LogP ]:
2.69740

Related Compounds

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