1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

Modify Date: 2024-01-02 14:44:58

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Structure
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride structure
 Common Name 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
CAS Number 25952-53-8 Molecular Weight 191.70
Density 0.877 g/mL at 20 °C(lit.) Boiling Point 269.1ºC at 760 mmHg
Molecular Formula C8H18ClN3 Melting Point 110-115 °C(lit.)
MSDS Chinese USA Flash Point 107.9ºC
Symbol GHS05 GHS07
GHS05, GHS07		 Signal Word Danger

 Use of 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride


1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is a carbodiimide reagent that can form nucleic acid and compounds with amide bonds. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride accelerates the formation reaction of esters, amides, and peptides, as a condensing and dehydrating agent, which are often used for polynucleotide synthesis, anhydroxydation, lactonization and esterification[1][2].

 Names

Name 3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine,hydrochloride
Synonym More Synonyms

  Biological Activity

Description 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is a carbodiimide reagent that can form nucleic acid and compounds with amide bonds. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride accelerates the formation reaction of esters, amides, and peptides, as a condensing and dehydrating agent, which are often used for polynucleotide synthesis, anhydroxydation, lactonization and esterification[1][2].
Related Catalog
In Vitro 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCl) is a very useful agent to form amide bonds (peptide bonds) in an aqueous medium[1]. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC•HCl), is widely used for polyaniline-carbon nanotube preparation for a cholesterol biosensor, precolumn derivatization of aliphatic amines for HPLC, molecular beacons formation for DNA reseach, sensor preparation for calcium detection, the fluorescent determination of carboxylic acids, and solidphase microsequencing of peptides[2]. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC•HCl) is an aminoaldehyde dehydrogenase (AMADH) inhibitor, while its inhibition on glutamate decarboxylase (GAD) is insignificant[3].
References

[1]. Kunihiko Seno, et al. Spectrophotometric determination of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride by flow injection analysis. Anal Sci. 2008 Apr;24(4):505-8.

[2]. Kunihiko Seno, et al. Determination of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride by flow-injection analysis based on a specific condensation reaction between malonic acid and ethylenediamine. Anal Sci. 2009 Mar;25(3):389-93.

[3]. Runqiang Yang, et al. AMADH inhibitor optimization and its effects on GABA accumulation in soybean sprouts under NaCl-CaCl 2 treatment. 3 Biotech. 2019 May;9(5):184.

 Chemical & Physical Properties

Density 0.877 g/mL at 20 °C(lit.)
Boiling Point 269.1ºC at 760 mmHg
Melting Point 110-115 °C(lit.)
Molecular Formula C8H18ClN3
Molecular Weight 191.70
Flash Point 107.9ºC
Exact Mass 191.118927
PSA 27.96000
LogP 1.93390
Vapour Pressure 0.171mmHg at 25°C
Index of Refraction n20/D 1.461
Storage condition −20°C
Stability Stable, but sensitive to moisture. Incompatible with strong acids, strong oxidizing agents, moisture.
Water Solubility Soluble

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36/37/39-S45-S37/39
RIDADR UN 2735 8/PG 3
WGK Germany 3
RTECS FF2200000
HS Code 29252000

 Customs

HS Code 2925290090
Summary 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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 Synonyms

N-(3-(Dimethylamino)propyl)-N'-ethylcarbodiimide hydrochloride
1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride
Carbodiimide, (3-dimethylaminopropyl)ethyl-, monohydrochloride
EDC HCL
EDAC,Hydrochloride
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide hydrochloride
Carbodiimide, [3-(dimethylamino)propyl]ethyl-, hydrochloride
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride
1-Ethyl-3-[3-(dimethylamino)propyl]carbodiimide monohydrochloride
1-Ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride
N'-(Ethylcarbonimidoyl)-N,N-dimethyl-1,3-propanediamine hydrochloride
N-[3-(Dimethylamino)propyl]-N'-ethylcarbodiimide hydrochloride
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride
N-Ethyl-N'-[3-(dimethylamino)propyl]carbodiimide hydrochloride
1,3-Propanediamine, N-(ethylcarbonimidoyl)-N,N-dimethyl-, hydrochloride (1:1)
1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride
EDCI
1-ethyl-3(3-dimethylaminopropyl) carbodiimide hydrochloride
EINECS 217-579-2
Carbodiimide, [3-(dimethylamino)propyl]ethyl-, monohydrochloride
1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, hydrochloride
1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent
EDAP
N-[3-(Dimethylamino)propyl]-N'-ethylcarbodiimide hydrochloride (1:1)
Carbodiimide, (3-(dimethylamino)propyl)ethyl-, monohydrochloride
Carbodiimide, (3-dimethylaminopropyl)ethyl-, hydrochloride
3-(3-Dimethylaminopropyl)-1-Ethylcarbodiimide Hydrochloride
MFCD00044916
1-(3-(dimethylamino)-propyl)-3-ethylcarbodiimide hydrochloride
N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride
EDC.HCl
EDC hydrochloride
edac hcl
wsc hcl
1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride
EDC·HCl
1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE,EDC.HCl
Top Suppliers:I want be here
  • Nanjing Peptide Biotech Ltd
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  • Product Name: EDC·HCl
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  • Purity: 98.0%
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Chemsrc provides CAS#:25952-53-8 MSDS, density, melting point, boiling point, structure, etc. Its name is 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride>> amp version: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

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