Tinlorafenib
Modify Date: 2025-08-25 11:20:16
Tinlorafenib structure
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Common Name | Tinlorafenib | ||
|---|---|---|---|---|
| CAS Number | 2573781-75-4 | Molecular Weight | 456.89 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H19ClF2N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TinlorafenibTinlorafenib (PF-07284890) (compound 10) is an orally active BRAF kinase inhibitor, with IC50s of 4.25 and 2.7 nM for BRAFV600E/V600K respectively. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies[1]. |
| Name | Tinlorafenib |
|---|
| Description | Tinlorafenib (PF-07284890) (compound 10) is an orally active BRAF kinase inhibitor, with IC50s of 4.25 and 2.7 nM for BRAFV600E/V600K respectively. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies[1]. |
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| Related Catalog | |
| Target |
BRafV600E:4.25 nM (IC50) BRafV600K:2.7 nM (IC50) |
| References |
| Molecular Formula | C19H19ClF2N4O3S |
|---|---|
| Molecular Weight | 456.89 |
| InChIKey | VVLVISDSGRHLMB-UHFFFAOYSA-N |
| SMILES | Cc1c(Nc2c(F)ccc(NS(=O)(=O)CCCF)c2Cl)ccc2ncn(C)c(=O)c12 |