2573781-75-4

2573781-75-4 structure

Name: Tinlorafenib
Chemical Name: Tinlorafenib
CAS Number: 2573781-75-4
Molecular Formula: C₁₉H₁₉ClF₂N₄O₃S
Molecular Weight: 456.89
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2022-08-31 12:41:32
Modify Date: 2024-01-10 18:29:09
Tinlorafenib (PF-07284890) (compound 10) is an orally active BRAF kinase inhibitor, with IC50s of 4.25 and 2.7 nM for BRAFV600E/V600K respectively. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies[1].

Name	Tinlorafenib

Description	Tinlorafenib (PF-07284890) (compound 10) is an orally active BRAF kinase inhibitor, with IC50s of 4.25 and 2.7 nM for BRAFV600E/V600K respectively. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf
Target	BRafV600E:4.25 nM (IC50) BRafV600K:2.7 nM (IC50)
References	[1]. Barbour, et al. Quinazolin-4-one derivatives useful for the treatment of braf-associated diseases and disorders. WO2020261156A1.

Molecular Formula	C₁₉H₁₉ClF₂N₄O₃S
Molecular Weight	456.89