Tinlorafenib

Names

[ Name ]:
Tinlorafenib

Biological Activity

[Description]:

Tinlorafenib (PF-07284890) (compound 10) is an orally active BRAF kinase inhibitor, with IC50s of 4.25 and 2.7 nM for BRAFV600E/V600K respectively. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> Raf

[Target]

BRafV600E:4.25 nM (IC50)

BRafV600K:2.7 nM (IC50)

[References]

[1]. Barbour, et al. Quinazolin-4-one derivatives useful for the treatment of braf-associated diseases and disorders. WO2020261156A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₉ClF₂N₄O₃S

[ Molecular Weight ]:
456.89

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.