1-(2-(trifluoromethyl)phenyl)-1h-imidazole

Modify Date: 2024-01-26 18:52:13

1-(2-(trifluoromethyl)phenyl)-1h-imidazole Structure
1-(2-(trifluoromethyl)phenyl)-1h-imidazole structure
Common Name 1-(2-(trifluoromethyl)phenyl)-1h-imidazole
CAS Number 25371-96-4 Molecular Weight 212.171
Density 1.3±0.1 g/cm3 Boiling Point 288.3±40.0 °C at 760 mmHg
Molecular Formula C10H7F3N2 Melting Point 43 °C
MSDS USA Flash Point 128.2±27.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 1-(2-(trifluoromethyl)phenyl)-1h-imidazole


TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects[1][2].

 Names

Name 1-[2-(trifluoromethyl)phenyl]imidazole
Synonym More Synonyms

  Biological Activity

Description TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects[1][2].
Related Catalog
In Vitro TRIM is a relatively weak inhibitor of eNOS (IC50, 1057.5 µM)[1].
References

[1]. Handy RL, et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol. 1995;116(5):2349-2350.

[2]. Volke V, et al. Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res. 2003;140(1-2):141-147.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 288.3±40.0 °C at 760 mmHg
Melting Point 43 °C
Molecular Formula C10H7F3N2
Molecular Weight 212.171
Flash Point 128.2±27.3 °C
Exact Mass 212.056137
PSA 17.82000
LogP 2.55
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.522
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933290090

 Customs

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles46

More Articles
Magnetic high throughput screening system for the development of nano-sized molecularly imprinted polymers for controlled delivery of curcumin.

Analyst 140(9) , 3113-20, (2015)

Curcumin is a versatile anti-inflammatory and anti-cancer agent known for its low bioavailability, which could be improved by developing materials capable of binding and releasing drug in a controlled...

Cholesterol-based polymeric monolithic columns for capillary liquid chromatography.

J. Chromatogr. A. 1373 , 114-23, (2014)

A novel, cholesterol-based polymeric monolithic stationary phase for capillary liquid chromatography, was prepared by thermally initiated in-situ polymerization. Cholesteryl methacrylate (CholMA) was ...

Robust naphthyl methacrylate monolithic column for high performance liquid chromatography of a wide range of solutes.

J. Chromatogr. A. 1409 , 166-72, (2015)

An organic monolithic column based on the co-polymerization of 2-naphthyl methacrylate (NAPM) as the functional monomer and trimethylolpropane trimethacrylate (TRIM) as the crosslinker was introduced ...

 Synonyms

1-[2-(Trifluoromethyl)phenyl]-1H-imidazole
1-(2-(trifluoromethyl)phenyl)-1h-imidazole
1-[2-(Trifluoromethyl)phenyl]imidazole
Trim
MFCD00041206
1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]-
1H-Imidazole, 1-(2-(trifluoromethyl)phenyl)-