A-205804
Modify Date: 2024-01-10 17:41:00
A-205804 structure
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Common Name | A-205804 | ||
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| CAS Number | 251992-66-2 | Molecular Weight | 300.399 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 581.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H12N2OS2 | Melting Point | 198-199℃ | |
| MSDS | N/A | Flash Point | 305.4±28.7 °C | |
Use of A-205804A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases[1]. |
| Name | 4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridine-2-carboxamide |
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| Synonym | More Synonyms |
| Description | A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases[1]. |
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| Related Catalog | |
| Target |
IC50: 20 nM (E-selectin), 25 nM (ICAM-1)[1] |
| In Vitro | A-205804 exhibits Cellular Toxicities for HUVEC with an IC50 of 152 μM[1]. A-205804 is an effective inhibitor of cell-cell adhesion in an in vitro flow experiment, demonstrating relevance in a model physiological system[1]. |
| In Vivo | A-205804 (5 mg/kg; p.o.) shows a half-life of 1 hour for rat[1]. A-205804 (10 mg/kg; p.o.; 3 times per week; for 2 weeks) attenuates the E-selectin expression on the endothelial vascular niche cells in mice[2]. Animal Model: C57BL/6 mice[2] Dosage: 10 mg/kg Administration: Oral administration, 3 times per week, for 2 weeks Result: Efficiently decreased the expression of E-selectin on the endothelial vascular niche cells Animal Model: Rat[1] Dosage: 5 mg/kg (Pharmacokinetic Analysis) Administration: Oral administration Result: t1/2 = 1 hour |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 581.3±45.0 °C at 760 mmHg |
| Melting Point | 198-199℃ |
| Molecular Formula | C15H12N2OS2 |
| Molecular Weight | 300.399 |
| Flash Point | 305.4±28.7 °C |
| Exact Mass | 300.039093 |
| PSA | 109.52000 |
| LogP | 3.07 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.738 |
| Storage condition | Store at +4°C |
| Hazard Codes | Xi |
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A-205804 CAS#:251992-66-2 |
| Literature: Abbott Laboratories Patent: US6232320 B1, 2001 ; |
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A-205804 CAS#:251992-66-2 |
| Literature: Stewart; Bhatia; McCarty; Patel; Staeger; Arendsen; Gunawardana; Melcher; Zhu; Boyd; Fry; Cool; Kiflie; Lartey; Marsh; Kempf-Grote; Kilgannon; Wisdom; Meyer; Gallatin; Okasinskit Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 988 - 1002 |
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A-205804 CAS#:251992-66-2 |
| Literature: Stewart; Bhatia; McCarty; Patel; Staeger; Arendsen; Gunawardana; Melcher; Zhu; Boyd; Fry; Cool; Kiflie; Lartey; Marsh; Kempf-Grote; Kilgannon; Wisdom; Meyer; Gallatin; Okasinskit Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 988 - 1002 |
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~%
A-205804 CAS#:251992-66-2 |
| Literature: Stewart; Bhatia; McCarty; Patel; Staeger; Arendsen; Gunawardana; Melcher; Zhu; Boyd; Fry; Cool; Kiflie; Lartey; Marsh; Kempf-Grote; Kilgannon; Wisdom; Meyer; Gallatin; Okasinskit Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 988 - 1002 |
|
~%
A-205804 CAS#:251992-66-2 |
| Literature: Stewart; Bhatia; McCarty; Patel; Staeger; Arendsen; Gunawardana; Melcher; Zhu; Boyd; Fry; Cool; Kiflie; Lartey; Marsh; Kempf-Grote; Kilgannon; Wisdom; Meyer; Gallatin; Okasinskit Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 988 - 1002 |
![4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxylic acid structure](https://www.chemsrc.com/caspic/260/251992-65-1.png)
![3-[(4-methylphenyl)thio]-5-chloro-4-pyridinecarboxyaldehyde structure](https://www.chemsrc.com/caspic/300/313216-16-9.png)
| Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]- |
| hms3269o07 |
| 4-[(4-Methylphenyl)sulfanyl]thieno[2,3-c]pyridine-2-carboxamide |
| unii-tp7tb1sszd |