Cyclic Arg-Gly-Asp-D-Tyr-Lys

Modify Date: 2025-08-28 17:31:33

Cyclic Arg-Gly-Asp-D-Tyr-Lys Structure
Cyclic Arg-Gly-Asp-D-Tyr-Lys structure
 Common Name Cyclic Arg-Gly-Asp-D-Tyr-Lys
CAS Number 250612-42-1 Molecular Weight 847.72
Density N/A Boiling Point N/A
Molecular Formula C31H43F6N9O12 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cyclic Arg-Gly-Asp-D-Tyr-Lys


Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

 Names

Name Cyclo(RGDyK)
Synonym More Synonyms

 Cyclic Arg-Gly-Asp-D-Tyr-Lys Biological Activity

Description Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
Related Catalog
Target

IC50: 20 nM (αVβ3 Integrin), 3000 nM (αIIbβ3 Integrin), 4000 nM (αVβ5 Integrin)[1]

In Vitro Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5 (IC50=4000 nM) and αIIbβ3 (IC50=3000 nM)[1].
References

[1]. Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42(2):326-36.

 Chemical & Physical Properties

Molecular Formula C31H43F6N9O12
Molecular Weight 847.72
Storage condition -20℃

 Synonyms

Cyclic Arg-Gly-Asp-D-Tyr-Lys
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