250612-42-1

250612-42-1 structure

Name: Cyclic Arg-Gly-Asp-D-Tyr-Lys
Chemical Name: Cyclo(RGDyK)
CAS Number: 250612-42-1
Molecular Formula: C₃₁H₄₃F₆N₉O₁₂
Molecular Weight: 847.72
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2016-10-09 11:36:03
Modify Date: 2025-08-28 17:31:33
Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Name	Cyclo(RGDyK)
Synonyms	Cyclic Arg-Gly-Asp-D-Tyr-Lys

Description	Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
Related Catalog	Signaling Pathways >> Cytoskeleton >> Integrin Research Areas >> Cancer
Target	IC50: 20 nM (αVβ3 Integrin), 3000 nM (αIIbβ3 Integrin), 4000 nM (αVβ5 Integrin)[1]
In Vitro	Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5 (IC50=4000 nM) and αIIbβ3 (IC50=3000 nM)[1].
References	[1]. Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42(2):326-36.