Pociredir

Modify Date: 2024-04-07 22:09:46

Pociredir Structure
Pociredir structure
Common Name Pociredir
CAS Number 2490674-02-5 Molecular Weight 403.41
Density N/A Boiling Point N/A
Molecular Formula C22H18FN5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pociredir


Pociredir (FTX-6058) is a potent, selective and orally active small-molecule inhibitor of embryonic ectoderm development (EED) with KD value of 0.163 nM. Pociredir (FTX-6058) can be used for the research of inflammatory or hemoglobinopathies, such as sickle cell disease (SCD) [1][2].

 Names

Name Pociredir

 Pociredir Biological Activity

Description Pociredir (FTX-6058) is a potent, selective and orally active small-molecule inhibitor of embryonic ectoderm development (EED) with KD value of 0.163 nM. Pociredir (FTX-6058) can be used for the research of inflammatory or hemoglobinopathies, such as sickle cell disease (SCD) [1][2].
Related Catalog
In Vivo Pociredir (FTX-6058) (QD, 5 mg/kg) reduces the H3K27me3 levels in the Townes mouse model of sickle cell disease (SCD). Pociredir (FTX-6058) (QD, 5 mg/kg) increases the levels of red blood cells and total hemoglobin, ameliorates hemolysis in the Townes mouse model of sickle cell disease (SCD) [1].
References

[1]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.

[2]. DavidMatson, et al. Ftx-6058 Induces Fetal Hemoglobin Production and Ameliorates Disease Pathology in Sickle Cell Mice. Blood (2021) 138 (Supplement 1): 2018.

 Chemical & Physical Properties

Molecular Formula C22H18FN5O2
Molecular Weight 403.41
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