pociredir

Names

[ Name ]:
pociredir

Biological Activity

[Description]:

Pociredir (FTX-6058) is a potent, selective and orally active small-molecule inhibitor of embryonic ectoderm development (EED) with KD value of 0.163 nM. Pociredir (FTX-6058) can be used for the research of inflammatory or hemoglobinopathies, such as sickle cell disease (SCD) [1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[In Vivo]

Pociredir (FTX-6058) (QD, 5 mg/kg) reduces the H3K27me3 levels in the Townes mouse model of sickle cell disease (SCD). Pociredir (FTX-6058) (QD, 5 mg/kg) increases the levels of red blood cells and total hemoglobin, ameliorates hemolysis in the Townes mouse model of sickle cell disease (SCD) [1].

[References]

[1]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.

[2]. DavidMatson, et al. Ftx-6058 Induces Fetal Hemoglobin Production and Ameliorates Disease Pathology in Sickle Cell Mice. Blood (2021) 138 (Supplement 1): 2018.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₈FN₅O₂

[ Molecular Weight ]:
403.41

Related Compounds

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