2490674-02-5

2490674-02-5 structure

Name: pociredir
Chemical Name: Pociredir
CAS Number: 2490674-02-5
Molecular Formula: C₂₂H₁₈FN₅O₂
Molecular Weight: 403.41
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2022-09-11 13:26:36
Modify Date: 2024-04-07 22:09:46
Pociredir (FTX-6058) is a potent, selective and orally active small-molecule inhibitor of embryonic ectoderm development (EED) with KD value of 0.163 nM. Pociredir (FTX-6058) can be used for the research of inflammatory or hemoglobinopathies, such as sickle cell disease (SCD) [1][2].

Name	Pociredir

Description	Pociredir (FTX-6058) is a potent, selective and orally active small-molecule inhibitor of embryonic ectoderm development (EED) with KD value of 0.163 nM. Pociredir (FTX-6058) can be used for the research of inflammatory or hemoglobinopathies, such as sickle cell disease (SCD) [1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Epigenetics >> Histone Methyltransferase
In Vivo	Pociredir (FTX-6058) (QD, 5 mg/kg) reduces the H3K27me3 levels in the Townes mouse model of sickle cell disease (SCD). Pociredir (FTX-6058) (QD, 5 mg/kg) increases the levels of red blood cells and total hemoglobin, ameliorates hemolysis in the Townes mouse model of sickle cell disease (SCD) [1].
References	[1]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022. [2]. DavidMatson, et al. Ftx-6058 Induces Fetal Hemoglobin Production and Ameliorates Disease Pathology in Sickle Cell Mice. Blood (2021) 138 (Supplement 1): 2018.

Molecular Formula	C₂₂H₁₈FN₅O₂
Molecular Weight	403.41