HDAC8/BRPF1-IN-1
Modify Date: 2025-08-26 19:17:16
HDAC8/BRPF1-IN-1 structure
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Common Name | HDAC8/BRPF1-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 2484255-85-6 | Molecular Weight | 417.44 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H19N3O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HDAC8/BRPF1-IN-1HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6[1]. |
| Name | HDAC8/BRPF1-IN-1 |
|---|
| Description | HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6[1]. |
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| Related Catalog | |
| Target |
hHDAC8:443 nM (IC50) hBRPF1:67 nM (Ki) |
| In Vitro | HDAC8/BRPF1-IN-1 (Compound 23a) (4-100 μM; 24 h) shows antiproliferative activity against acute myeloid leukemia cells[1]. Cell Proliferation Assay[1] Cell Line: Acute myeloid leukemia cells THP-1 and HL60 Concentration: 4, 20 and 100 μM Incubation Time: 24 h Result: Inhibited THP-1 and HL60 cells growth. |
| References |
| Molecular Formula | C19H19N3O6S |
|---|---|
| Molecular Weight | 417.44 |