SB 328437
SB 328437 structure
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Common Name | SB 328437 | ||
|---|---|---|---|---|
| CAS Number | 247580-43-4 | Molecular Weight | 378.37800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H18N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of SB 328437SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM[1]. |
| Name | methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate |
|---|---|
| Synonym | More Synonyms |
| Description | SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
CCR3:4.5 nM (IC50) |
| References |
| Molecular Formula | C21H18N2O5 |
|---|---|
| Molecular Weight | 378.37800 |
| Exact Mass | 378.12200 |
| PSA | 104.71000 |
| LogP | 4.36010 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H400 |
| Precautionary Statements | P273 |
| RIDADR | UN 3077 9 / PGIII |
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CCR3 antagonists: a survey of the patent literature.
Expert Opin. Ther. Pat. 19(8) , 1109-32, (2009) Since the mid-1990s, there has been significant effort invested in the discovery and clinical development of CC chemokine receptor-3 (CCR3) antagonists as potential therapeutics for airway disease.A p... |
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Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists.
Int. Immunol. 19(8) , 913-21, (2007) The effects of selective CC chemokine receptor (CCR)-3 antagonists on antigen-induced leukocyte accumulation in the lungs of mice adoptively transferred with in vitro-differentiated T(h)1 and T(h)2 we... |
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CCR3 and choroidal neovascularization.
PLoS ONE 6 , e17106, (2011) Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly in industrialized countries. The "wet" AMD, characterized by the development of choroidal neovacula... |
| L-Phenylalanine,N-(1-naphthalenylcarbonyl)-4-nitro-,methyl ester |
| (S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate |
| N-(1-NAPHTHALENYLCARBONYL)-4-NITRO-L-PHENYLALANINE METHYL ESTER |
| L-Phenylalanine (N-(1-naphthalenylcarbonyl)-4-nitro |