SIRT1-IN-2
Modify Date: 2025-08-26 18:21:05
SIRT1-IN-2 structure
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Common Name | SIRT1-IN-2 | ||
|---|---|---|---|---|
| CAS Number | 2470969-89-0 | Molecular Weight | 250.72 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H15ClN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SIRT1-IN-2SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC50 of 1.6 μM[1]. |
| Name | SIRT1-IN-2 |
|---|
| Description | SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC50 of 1.6 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
SIRT1:1.6 μM (IC50) SIRT2:39 μM (IC50) |
| In Vitro | SIRT1-IN-2 (compound 3h) (0-100 μM, 48 h) inhibits the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, and shows significantly less cytotoxic on 293T cells and HUVEC[1]. Cell Cytotoxicity Assay Cell Line: Human cancer cell lines (K562, HCT-116, H460, HepG2, A549, HT-29, MCF-7) and normal cell lines (293T, HUVEC). [1] Concentration: 0, 0.01，0.1，1，10，100 μM Incubation Time: 48 h Result: Inhibited the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, with IC50 values of 51, 37, 40, 48, and 48 μM, respectively. And showed significantly less cytotoxic on 293T cells and HUVEC, with IC50 values of > 100 and 45 μM, respectively. |
| References |
| Molecular Formula | C13H15ClN2O |
|---|---|
| Molecular Weight | 250.72 |
| InChIKey | IFPRJIBVYBLMFW-UHFFFAOYSA-N |
| SMILES | CC(C)c1c(CC(N)=O)[nH]c2ccc(Cl)cc12 |