BRD4 Inhibitor-28

Modify Date: 2025-08-25 15:59:29

BRD4 Inhibitor-28 structure	Common Name	BRD4 Inhibitor-28
	CAS Number	2468960-80-5	Molecular Weight	387.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₁N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BRD4 Inhibitor-28

BRD4 Inhibitor-28 (Compound 18) is an orally active BRD4 Inhibitor. BRD4 Inhibitor-28 inhibits BRD40-BD1, BRD40-BD2 with IC50s of 15, 55 nM. BRD4 Inhibitor-28 also inhibits BRD2-BD1, BRD3-BD1, BRDT-BD1 with IC50s of 19, 25, 68 nM. BRD4 Inhibitor-28 has anti-melanoma activity[1].

Name	BRD4 Inhibitor-28

Description	BRD4 Inhibitor-28 (Compound 18) is an orally active BRD4 Inhibitor. BRD4 Inhibitor-28 inhibits BRD40-BD1, BRD40-BD2 with IC50s of 15, 55 nM. BRD4 Inhibitor-28 also inhibits BRD2-BD1, BRD3-BD1, BRDT-BD1 with IC50s of 19, 25, 68 nM. BRD4 Inhibitor-28 has anti-melanoma activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	15, 55, 19, 25, 68 nM (BRD40-BD1, BRD40-BD2, BRD2-BD1, BRD3-BD1, BRDT-BD1BRD2-BD1, BRD3-BD1, BRDT-BD1)[1]
References	[1]. Horai Y, et al. Discovery of a potent, orally available tricyclic derivative as a novel BRD4 inhibitor for melanoma. Bioorg Med Chem. 2023 Aug 26;93:117461.

Molecular Formula	C₂₃H₂₁N₃O₃
Molecular Weight	387.43
InChIKey	QTVSDAUHDJBCAA-UHFFFAOYSA-N
SMILES	Cc1cc(-c2cc3c4c(c2)n(Cc2ccccc2)c(=O)n4CCO3)cn(C)c1=O

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BRD4 Inhibitor-28

Use of BRD4 Inhibitor-28

Names

BRD4 Inhibitor-28 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.