BRD4 Inhibitor-28

Names

[ CAS No. ]:
2468960-80-5

[ Name ]:
BRD4 Inhibitor-28

Biological Activity

[Description]:

BRD4 Inhibitor-28 (Compound 18) is an orally active BRD4 Inhibitor. BRD4 Inhibitor-28 inhibits BRD40-BD1, BRD40-BD2 with IC50s of 15, 55 nM. BRD4 Inhibitor-28 also inhibits BRD2-BD1, BRD3-BD1, BRDT-BD1 with IC50s of 19, 25, 68 nM. BRD4 Inhibitor-28 has anti-melanoma activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

15, 55, 19, 25, 68 nM (BRD40-BD1, BRD40-BD2, BRD2-BD1, BRD3-BD1, BRDT-BD1BRD2-BD1, BRD3-BD1, BRDT-BD1)[1]


[References]

[1]. Horai Y, et al. Discovery of a potent, orally available tricyclic derivative as a novel BRD4 inhibitor for melanoma. Bioorg Med Chem. 2023 Aug 26;93:117461.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H21N3O3

[ Molecular Weight ]:
387.43

Related Compounds

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