2468960-80-5

2468960-80-5 structure

Name: BRD4 Inhibitor-28
Chemical Name: BRD4 Inhibitor-28
CAS Number: 2468960-80-5
Molecular Formula: C₂₃H₂₁N₃O₃
Molecular Weight: 387.43
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2024-04-09 13:24:52
Modify Date: 2024-04-09 13:24:52
BRD4 Inhibitor-28 (Compound 18) is an orally active BRD4 Inhibitor. BRD4 Inhibitor-28 inhibits BRD40-BD1, BRD40-BD2 with IC50s of 15, 55 nM. BRD4 Inhibitor-28 also inhibits BRD2-BD1, BRD3-BD1, BRDT-BD1 with IC50s of 19, 25, 68 nM. BRD4 Inhibitor-28 has anti-melanoma activity[1].

Name	BRD4 Inhibitor-28

Description	BRD4 Inhibitor-28 (Compound 18) is an orally active BRD4 Inhibitor. BRD4 Inhibitor-28 inhibits BRD40-BD1, BRD40-BD2 with IC50s of 15, 55 nM. BRD4 Inhibitor-28 also inhibits BRD2-BD1, BRD3-BD1, BRDT-BD1 with IC50s of 19, 25, 68 nM. BRD4 Inhibitor-28 has anti-melanoma activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	15, 55, 19, 25, 68 nM (BRD40-BD1, BRD40-BD2, BRD2-BD1, BRD3-BD1, BRDT-BD1BRD2-BD1, BRD3-BD1, BRDT-BD1)[1]
References	[1]. Horai Y, et al. Discovery of a potent, orally available tricyclic derivative as a novel BRD4 inhibitor for melanoma. Bioorg Med Chem. 2023 Aug 26;93:117461.

Molecular Formula	C₂₃H₂₁N₃O₃
Molecular Weight	387.43