Anticancer agent 47
Modify Date: 2024-01-14 11:45:29
Anticancer agent 47 structure
|
Common Name | Anticancer agent 47 | ||
|---|---|---|---|---|
| CAS Number | 2461795-23-1 | Molecular Weight | 366.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H14N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Anticancer agent 47Anticancer agent 47 (compound 4j) is a potent anticancer agent. Anticancer agent 47 shows antiproliferative activities. Anticancer agent 47 induces apoptosis and cell cycle arrest at G0/G1 phase. Anticancer agent 47 shows shows antitumor activities in vivo[1]. |
| Name | Anticancer agent 47 |
|---|
| Description | Anticancer agent 47 (compound 4j) is a potent anticancer agent. Anticancer agent 47 shows antiproliferative activities. Anticancer agent 47 induces apoptosis and cell cycle arrest at G0/G1 phase. Anticancer agent 47 shows shows antitumor activities in vivo[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Anticancer agent 47 (compound 4j) shows antiproliferative activities with IC50s of 1.6, 0.72, 7.07 µM for HepG2, A549, H596 cells, respectively[1]. Anticancer agent 47 (0.8, 1.6, 3.2 µM; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase[1]. Anticancer agent 47 (5 µM; 5h) significantly increases ROS production[1]. Apoptosis Analysis[1] Cell Line: HepG2, H596 cells Concentration: 0.8, 1.6, 3.2 µM Incubation Time: 24 h Result: Induced apoptosis with the apoptotic cell rates were 14.23, 20.47 and 27.66% at 0.8, 1.6, 3.2 µM in HepG2 cell, respectively. Cell Cycle Analysis[1] Cell Line: HepG2 cells Concentration: 0.8, 1.6, 3.2 µM Incubation Time: 24 h Result: Showed 48.54%, 49.60% and 53.00% cells were at G0/G1 phase at 0.6, 1.2 and 2.4 µM, respectively. |
| In Vivo | Anticancer agent 47 (20 mg/kg; i.v.; once every 2 days for 19 days) shows antitumor activities[1]. Animal Model: BALB/c nude mice (HepG2 xenografts)[1] Dosage: 20 mg/kg Administration: I.v.; once every 2 days for 19 days Result: Effectively inhibited tumor growth with the 58.7% tumor inhibition rate. |
| References |
| Molecular Formula | C19H14N2O4S |
|---|---|
| Molecular Weight | 366.39 |