IHMT-TRK-284

Modify Date: 2024-04-12 08:13:37

IHMT-TRK-284 structure	Common Name	IHMT-TRK-284
	CAS Number	2416844-79-4	Molecular Weight	473.59
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₇N₇OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IHMT-TRK-284

IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC50 values of 10.5, 0.7, and 2.6 nM to TRKA, B, and C respectively. IHMT-TRK-284 displays great selectivity profile in the kinome and good in vivo antitumor efficacies[1].

Name	IHMT-TRK-284

Description	IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC50 values of 10.5, 0.7, and 2.6 nM to TRKA, B, and C respectively. IHMT-TRK-284 displays great selectivity profile in the kinome and good in vivo antitumor efficacies[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit
Target	TrkB:0.7 nM (IC50) TrkC:2.6 nM (IC50) TrkA:10.5 nM (IC50) PDGFRα:24.2 nM (IC50) PDGFRβ:95.7 nM (IC50) Abl1:83.6 nM (IC50) CSF1R:1.2 nM (IC50) KIT:2167 nM (IC50)
References	[1]. Beilei Wang, et al. Discovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistant mutants. Eur J Med Chem. 2020 Dec 1;207:112744.

Molecular Formula	C₂₅H₂₇N₇OS
Molecular Weight	473.59

DC Chemicals Limited
China
Product Name: IHMT-TRK-284
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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