2416844-79-4

2416844-79-4 structure

Name: IHMT-TRK-284
Chemical Name: IHMT-TRK-284
CAS Number: 2416844-79-4
Molecular Formula: C₂₅H₂₇N₇OS
Molecular Weight: 473.59
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-06-19 18:40:55
Modify Date: 2024-04-12 08:13:37
IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC50 values of 10.5, 0.7, and 2.6 nM to TRKA, B, and C respectively. IHMT-TRK-284 displays great selectivity profile in the kinome and good in vivo antitumor efficacies[1].

Name	IHMT-TRK-284

Description	IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC50 values of 10.5, 0.7, and 2.6 nM to TRKA, B, and C respectively. IHMT-TRK-284 displays great selectivity profile in the kinome and good in vivo antitumor efficacies[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit
Target	TrkB:0.7 nM (IC50) TrkC:2.6 nM (IC50) TrkA:10.5 nM (IC50) PDGFRα:24.2 nM (IC50) PDGFRβ:95.7 nM (IC50) Abl1:83.6 nM (IC50) CSF1R:1.2 nM (IC50) KIT:2167 nM (IC50)
References	[1]. Beilei Wang, et al. Discovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistant mutants. Eur J Med Chem. 2020 Dec 1;207:112744.

Molecular Formula	C₂₅H₂₇N₇OS
Molecular Weight	473.59