ZB-R-55
Modify Date: 2023-01-17 11:43:40
ZB-R-55 structure
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Common Name | ZB-R-55 | ||
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| CAS Number | 2416593-55-8 | Molecular Weight | 441.491 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H23N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ZB-R-55ZB-R-55 is a potent and selective RIPK1 inhibitor with IC50 of 5.7 nM, 10-fold more potent than GSK2982772.ZB-R-55 is a dual-mode RIPK1 inhibitors occupying both the allosteric and the ATP binding pockets.ZB-R-55 exhibits excellent kinase selectivity, good oral pharmacokinetics and good therapeutic effects in the LPS-induced sepsis model. |
| Name | ZB-R-55 |
|---|
| Description | ZB-R-55 is a potent and selective RIPK1 inhibitor with IC50 of 5.7 nM, 10-fold more potent than GSK2982772.ZB-R-55 is a dual-mode RIPK1 inhibitors occupying both the allosteric and the ATP binding pockets.ZB-R-55 exhibits excellent kinase selectivity, good oral pharmacokinetics and good therapeutic effects in the LPS-induced sepsis model. |
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| References | 1. Xiangbo Yang, et al. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202114922. |
| Molecular Formula | C25H23N5O3 |
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| Molecular Weight | 441.491 |