2416593-55-8
2416593-55-8 structure
- Name: ZB-R-55
- Chemical Name: ZB-R-55
- CAS Number: 2416593-55-8
- Molecular Formula: C25H23N5O3
- Molecular Weight: 441.491
- Create Date: 2022-06-30 20:17:21
- Modify Date: 2023-01-17 11:43:40
-
ZB-R-55 is a potent and selective RIPK1 inhibitor with IC50 of 5.7 nM, 10-fold more potent than GSK2982772.ZB-R-55 is a dual-mode RIPK1 inhibitors occupying both the allosteric and the ATP binding pockets.ZB-R-55 exhibits excellent kinase selectivity, good oral pharmacokinetics and good therapeutic effects in the LPS-induced sepsis model.
| Name | ZB-R-55 |
|---|
| Description | ZB-R-55 is a potent and selective RIPK1 inhibitor with IC50 of 5.7 nM, 10-fold more potent than GSK2982772.ZB-R-55 is a dual-mode RIPK1 inhibitors occupying both the allosteric and the ATP binding pockets.ZB-R-55 exhibits excellent kinase selectivity, good oral pharmacokinetics and good therapeutic effects in the LPS-induced sepsis model. |
|---|---|
| References | 1. Xiangbo Yang, et al. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202114922. |
| Molecular Formula | C25H23N5O3 |
|---|---|
| Molecular Weight | 441.491 |