ZB-R-55
Names
[ CAS No. ]:
2416593-55-8
[ Name ]:
ZB-R-55
Biological Activity
[Description]:
ZB-R-55 is a potent and selective RIPK1 inhibitor with IC50 of 5.7 nM, 10-fold more potent than GSK2982772.ZB-R-55 is a dual-mode RIPK1 inhibitors occupying both the allosteric and the ATP binding pockets.ZB-R-55 exhibits excellent kinase selectivity, good oral pharmacokinetics and good therapeutic effects in the LPS-induced sepsis model.
[References]
1. Xiangbo Yang, et al. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202114922.
Chemical & Physical Properties
[ Molecular Formula ]:
C25H23N5O3
[ Molecular Weight ]:
441.491
Related Compounds
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