L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester

Modify Date: 2024-01-09 13:34:47

L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester Structure
L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester structure
Common Name L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester
CAS Number 24164-06-5 Molecular Weight 245.31500
Density 1.015g/cm3 Boiling Point 293.5ºC at 760mmHg
Molecular Formula C12H23NO4 Melting Point N/A
MSDS N/A Flash Point 131.3ºC

 Use of L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester


NSC 135130 (compound 11a) is a BOC-protected ADC linker that can be linked to tubulin-targeting inhibitors.Can be used to synthesize drug conjugates[1].

 Names

Name methyl 3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]butanoate
Synonym More Synonyms

  Biological Activity

Description NSC 135130 (compound 11a) is a BOC-protected ADC linker that can be linked to tubulin-targeting inhibitors.Can be used to synthesize drug conjugates[1].
Related Catalog
References

[1]. Malkov AV, Vranková K, Cerný M, Kocovský P. On the selective N-methylation of BOC-protected amino acids. J Org Chem. 2009 Nov 6;74(21):8425-7.  

 Chemical & Physical Properties

Density 1.015g/cm3
Boiling Point 293.5ºC at 760mmHg
Molecular Formula C12H23NO4
Molecular Weight 245.31500
Flash Point 131.3ºC
Exact Mass 245.16300
PSA 55.84000
LogP 2.05090
Vapour Pressure 0.00172mmHg at 25°C
Index of Refraction 1.448

 Safety Information

HS Code 2922509090

 Synthetic Route

~97%

L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester Structure

L-Valine,N-[(1,...

CAS#:24164-06-5

Literature: Lan, Hong-Qiao; Ye, Jian-Liang; Wang, Ai-E; Ruan, Yuan-Ping; Huang, Pei-Qiang Chemistry - A European Journal, 2011 , vol. 17, # 3 p. 958 - 968

~99%

L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester Structure

L-Valine,N-[(1,...

CAS#:24164-06-5

Literature: Andrus, Merritt B.; Li, Wenke; Keyes, Robert F. Journal of Organic Chemistry, 1997 , vol. 62, # 16 p. 5542 - 5549

~75%

L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester Structure

L-Valine,N-[(1,...

CAS#:24164-06-5

Literature: Galeotti, Nathalie; Poncet, Joeel; Chiche, Laurent; Jouin, Patrick Journal of Organic Chemistry, 1993 , vol. 58, # 20 p. 5370 - 5376

~87%

L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester Structure

L-Valine,N-[(1,...

CAS#:24164-06-5

Literature: Di Gioia; Barattucci; Bonaccorsi; Leggio; Minuti; Romio; Temperini; Siciliano RSC Advances, 2014 , vol. 4, # 6 p. 2678 - 2686

~%

L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester Structure

L-Valine,N-[(1,...

CAS#:24164-06-5

Literature: Andrus, Merritt B.; Li, Wenke; Keyes, Robert F. Journal of Organic Chemistry, 1997 , vol. 62, # 16 p. 5542 - 5549

~%

L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester Structure

L-Valine,N-[(1,...

CAS#:24164-06-5

Literature: Di Gioia; Barattucci; Bonaccorsi; Leggio; Minuti; Romio; Temperini; Siciliano RSC Advances, 2014 , vol. 4, # 6 p. 2678 - 2686

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

methyl n-(tert-butoxycarbonyl)-n-methylvalinate
Boc-L-MeVal-OMe
N-Boc-N-Me-L-Val-OMe
N-Boc-N-methyl-L-valine methyl ester
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Price: ¥855/50 mg

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