L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester

Names

[ Name ]:
L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester

[Synonym ]:
methyl n-(tert-butoxycarbonyl)-n-methylvalinate
Boc-L-MeVal-OMe
N-Boc-N-Me-L-Val-OMe
N-Boc-N-methyl-L-valine methyl ester

Biological Activity

[Description]:

NSC 135130 (compound 11a) is a BOC-protected ADC linker that can be linked to tubulin-targeting inhibitors.Can be used to synthesize drug conjugates[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[References]

[1]. Malkov AV, Vranková K, Cerný M, Kocovský P. On the selective N-methylation of BOC-protected amino acids. J Org Chem. 2009 Nov 6;74(21):8425-7.

Chemical & Physical Properties

[ Density]:
1.015g/cm3

[ Boiling Point ]:
293.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₂₃NO₄

[ Molecular Weight ]:
245.31500

[ Flash Point ]:
131.3ºC

[ Exact Mass ]:
245.16300

[ PSA ]:
55.84000

[ LogP ]:
2.05090

[ Vapour Pressure ]:
0.00172mmHg at 25°C

[ Index of Refraction ]:
1.448

Safety Information

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%