PDE5/HDAC-IN-1
Modify Date: 2024-01-10 12:45:39
PDE5/HDAC-IN-1 structure
|
Common Name | PDE5/HDAC-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 2414921-48-3 | Molecular Weight | 553.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H29BrN4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PDE5/HDAC-IN-1PDE5/HDAC-IN-1 (Compound 26) is a potent phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50 values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cell apoptosis and shows anticancer activities[1]. |
| Name | PDE5/HDAC-IN-1 |
|---|
| Description | PDE5/HDAC-IN-1 (Compound 26) is a potent phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50 values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cell apoptosis and shows anticancer activities[1]. |
|---|---|
| Related Catalog | |
| Target |
PDE5:46.3 nM (IC50) HDAC1:2.45 μM (IC50) HDAC6:0.11 μM (IC50) HDAC8:0.12 μM (IC50) |
| In Vitro | PDE5/HDAC-IN-1 (Compound 26) shows growth inhibition with IC50 values of 12.35, 7.19 and 11.79 µM against HT-29, HCT-116 and SW-620 cells, respectively[1]. PDE5/HDAC-IN-1 shows cytotoxic activity with IC50 values of 1.9, 1.5, 2.5, 5.5, 9.8, 18.6, 2 and 28.2 μM against Molt 4, Sup-T1, K562, AGS, PC-3, LNCaP, T47D and CCD966SK, respectively[1]. |
| References |
| Molecular Formula | C27H29BrN4O4 |
|---|---|
| Molecular Weight | 553.45 |