JAK/HDAC-IN-1
Modify Date: 2025-09-11 12:50:01
JAK/HDAC-IN-1 structure
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Common Name | JAK/HDAC-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 2284621-75-4 | Molecular Weight | 450.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H21Cl2N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JAK/HDAC-IN-1JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively[1]. |
| Name | JAK/HDAC-IN-1 |
|---|
| Description | JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively[1]. |
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| Related Catalog | |
| Target |
JAK2:4 nM (IC50) JAK1:4.8 nM (IC50) JAK3:7.4 nM (IC50) Tyk2:49 nM (IC50) HDAC:2 nM (IC50) HDAC2:14 nM (IC50) HDAC6:120 nM (IC50) HDAC8:2470 nM (IC50) |
| In Vitro | JAK/HDAC-IN-1 (Compound 8m) exhibits IC50s of 4.8, 7.4 and 49 nM for JAK1, JAK3 and TYK2, and 14, 120, 2470 nM for HDAC2, HDAC6 and HDAC8, respectively[1]. |
| References |
| Molecular Formula | C19H21Cl2N7O2 |
|---|---|
| Molecular Weight | 450.32 |