Aniline-MPB-amino-C3-PBD
Modify Date: 2025-08-23 19:15:48
Aniline-MPB-amino-C3-PBD structure
|
Common Name | Aniline-MPB-amino-C3-PBD | ||
|---|---|---|---|---|
| CAS Number | 2412923-79-4 | Molecular Weight | 758.86 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C42H46N8O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Aniline-MPB-amino-C3-PBDAniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1]. |
| Name | Aniline-MPB-amino-C3-PBD |
|---|
| Description | Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1]. |
|---|---|
| Related Catalog | |
| Target |
Pyrrolobenzodiazepines |
| In Vitro | Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12 with potency of 2 pg/mL determined[1]. |
| References |
[1]. David Edwin Thurston, et al. Polycyclic amides as cytotoxic agents. WO2020049286A1. |
| Molecular Formula | C42H46N8O6 |
|---|---|
| Molecular Weight | 758.86 |
| InChIKey | IRTLLBFDZDUFNC-YTTGMZPUSA-N |
| SMILES | COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3ccc(-c4cc(C(=O)Nc5ccc(N)cc5)n(C)c4)cc3)n(C)c1)NCC1CCCCN1C2=O |