5-HT6/5-HT2A receptor ligand-2

Modify Date: 2025-09-21 13:32:30

5-HT6/5-HT2A receptor ligand-2 structure	Common Name	5-HT6/5-HT2A receptor ligand-2
	CAS Number	2411088-16-7	Molecular Weight	351.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₈FN₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 5-HT6/5-HT2A receptor ligand-2

5-HT6/5-HT2A receptor ligand-2 (compound 42) is a brain-penetrant dual 5-HT6/5-HT2A receptor antagonist, with a Ki of 25 nM and 32 nM, respectively. 5-HT6/5-HT2A receptor ligand-2 shows pro-cognitive properties[1].

Name	5-HT6/5-HT2A receptor ligand-2

Description	5-HT6/5-HT2A receptor ligand-2 (compound 42) is a brain-penetrant dual 5-HT6/5-HT2A receptor antagonist, with a Ki of 25 nM and 32 nM, respectively. 5-HT6/5-HT2A receptor ligand-2 shows pro-cognitive properties[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT6 Receptor:25 nM (Ki) 5-HT2A Receptor:32 nM (Ki)
References	[1]. Staroń J, et, al. Virtual screening-driven discovery of dual 5-HT 6/5-HT 2A receptor ligands with pro-cognitive properties. Eur J Med Chem. 2020 Jan 1;185:111857.

Molecular Formula	C₂₀H₁₈FN₃O₂
Molecular Weight	351.37

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