Topoisomerase IIα-IN-1

Modify Date: 2025-09-20 20:19:36

Topoisomerase IIα-IN-1 structure	Common Name	Topoisomerase IIα-IN-1
	CAS Number	2407521-87-1	Molecular Weight	420.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₀N₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Topoisomerase IIα-IN-1

Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines[1].

Name	Topoisomerase IIα-IN-1

Description	Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	topoisomerase II alpha topoisomerase II beta
In Vitro	Topoisomerase IIα-IN-1 (compound 2) shows antiproliferative activity in cancer cell lines (CCRF-CEM, CCRF-SB, MT-4, HT-29, MCF-7, HeLa, ACHN, SKMEL-28, and G-361), with IC50 values of 0.02, 0.02, 0.01, 0.003, 0.007, 0.005, 0.008, 0.002, and 0.001 μM, respectively[1].
References	[1]. Pedatella S, et al. Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors. Eur J Med Chem. 2020 Feb 1;187:111960.

Molecular Formula	C₂₂H₂₀N₄O₅
Molecular Weight	420.42

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com