2538528-11-7
2538528-11-7 structure
- Name: Topoisomerase IIα-IN-3
- Chemical Name: Topoisomerase IIα-IN-3
- CAS Number: 2538528-11-7
- Molecular Formula: C29H20N6O2S
- Molecular Weight: 516.57
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-08-05 16:43:50
- Modify Date: 2024-01-08 10:00:24
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Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis[1].
| Name | Topoisomerase IIα-IN-3 |
|---|
| Description | Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis[1]. |
|---|---|
| Related Catalog | |
| Target |
topoisomerase II alpha |
| In Vitro | Topoisomerase IIα-IN-3 (Compound 12c) shows cytotoxic potential with IC50 values of 2.82 ± 0.10, 3.28 ± 0.43, 4.09 ± 0.59, 4.78 ± 1.29, 3.83 ± 0.9,4 3.18 ± 0.49 and 71.25 ± 7.95 μM against A549, MDA-MB-231, BT-474, HCT-116, HL-60, THP-1 and BEAS-2B cells, respectively[1]. |
| References |
| Molecular Formula | C29H20N6O2S |
|---|---|
| Molecular Weight | 516.57 |