FGFR4-IN-11

Modify Date: 2025-08-26 12:47:18

FGFR4-IN-11 Structure
FGFR4-IN-11 structure
 Common Name FGFR4-IN-11
CAS Number 2396664-85-8 Molecular Weight 527.57
Density N/A Boiling Point N/A
Molecular Formula C29H29N5O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FGFR4-IN-11


FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity[1].

 Names

Name FGFR4-IN-11

 FGFR4-IN-11 Biological Activity

Description FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity[1].
Related Catalog
Target

FGFR4:2.1 nM (IC50)

References

[1]. Zhong Z, et al. Discovery of Novel 7-Azaindole Derivatives as Selective Covalent Fibroblast Growth Factor Receptor 4 Inhibitors for the Treatment of Hepatocellular Carcinoma. J Med Chem. 2022 May 26;65(10):7278-7295.

 Chemical & Physical Properties

Molecular Formula C29H29N5O5
Molecular Weight 527.57
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FGFR4-IN-2
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HPK1-IN-11
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IDO1-IN-11
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eIF4A3-IN-11
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3-[5-oxo-4-(2-phenylethyl)-3,3a,5a,6,7,8,9,9a-octahydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-N-(2-phenylethyl)propanamide
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N-[(2-chlorophenyl)methyl]-3-[5-oxo-4-(2-phenylethyl)-3,3a,5a,6,7,8,9,9a-octahydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
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7-{[(1-methyl-1H-benzimidazol-2-yl)methyl]amino}-3-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
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3-phenyl-7-{[2-(2-thienyl)ethyl]amino}pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
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3-phenyl-7-((3-(trifluoromethyl)benzyl)amino)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
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N-[(4-methoxyphenyl)methyl]-3-[5-oxo-4-(2-phenylethyl)-3,3a,5a,6,7,8,9,9a-octahydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
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N-(3-methoxypropyl)-3-[5-oxo-4-(2-phenylethyl)-3,3a,5a,6,7,8,9,9a-octahydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
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3-[5-oxo-4-(2-phenylethyl)-3,3a,5a,6,7,8,9,9a-octahydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-N-(3-propan-2-yloxypropyl)propanamide
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7-(dimethylamino)-3-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
1396761-96-8
3-phenyl-7-{[1-(2-thienyl)ethyl]amino}pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
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Chemsrc provides FGFR4-IN-11(CAS#:2396664-85-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of FGFR4-IN-11 are included as well.>> amp version: FGFR4-IN-11

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