Articaine

Modify Date: 2024-01-02 10:27:04

Articaine structure	Common Name	Articaine
	CAS Number	23964-58-1	Molecular Weight	284.37500
	Density	1.178 g/cm3	Boiling Point	440.6ºC at 760 mmHg
	Molecular Formula	C₁₃H₂₀N₂O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	220.3ºC
	Symbol	GHS07	Signal Word	Warning

Use of Articaine

Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway[1][2][3].

Name	methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate
Synonym	More Synonyms

Description	Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
Target	NF-ĸB, NLRP3, sodium channel[2][3]
References	[1]. Yapp KE, et al. Articaine: a review of the literature. Br Dent J. 2011 Apr 9;210(7):323-9. [2]. Zhao G, et al. Local anesthetic articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22554. [3]. Snoeck M. Articaine: a review of its use for local and regional anesthesia. Local Reg Anesth. 2012;5:23-33.

Density	1.178 g/cm3
Boiling Point	440.6ºC at 760 mmHg
Molecular Formula	C₁₃H₂₀N₂O₃S
Molecular Weight	284.37500
Flash Point	220.3ºC
Exact Mass	284.11900
PSA	95.67000
LogP	2.63360
Vapour Pressure	5.79E-08mmHg at 25°C
Index of Refraction	1.556