Articaine

Names

[ Name ]:
Articaine

[Synonym ]:
4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid,methyl ester
Carticaine
Articainum [INN-Latin]
Methyl (4-methyl-3-(2-(propylamino)propionamido)-2-thiophencarboxylat)
Articaina [INN-Spanish]
3-(N-propyl-2-amino-propionylamino)-2-carbomethoxy-4-methylthiophene
Articaine
Articainum
Hoe-045
MFCD00190157
Articaina

Biological Activity

[Description]:

Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway[1][2][3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)

Research Areas >> Inflammation/Immunology

[Target]

NF-ĸB, NLRP3, sodium channel[2][3]

[References]

[1]. Yapp KE, et al. Articaine: a review of the literature. Br Dent J. 2011 Apr 9;210(7):323-9.

[2]. Zhao G, et al. Local anesthetic articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22554.

[3]. Snoeck M. Articaine: a review of its use for local and regional anesthesia. Local Reg Anesth. 2012;5:23-33.

Chemical & Physical Properties

[ Density]:
1.178 g/cm3

[ Boiling Point ]:
440.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₂₀N₂O₃S

[ Molecular Weight ]:
284.37500

[ Flash Point ]:
220.3ºC

[ Exact Mass ]:
284.11900

[ PSA ]:
95.67000

[ LogP ]:
2.63360

[ Vapour Pressure ]:
5.79E-08mmHg at 25°C

[ Index of Refraction ]:
1.556

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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