4,4'-Diamino-3,3'-biphenyldiol

Chemical FormulaC12H12N2O2
2373-98-0
CAS Number

---

Section II.Composition and Information on Ingredients
Chemical NameCAS Number Percent (%)TLV/PELToxicology Data
3,3'-Dihydroxybenzidine2373-98-0Min. 98.0This chemical is classified as aNot available.
(HPLC,T)carcinogen. There is no
acceptable exposure limit for a
carcinogen.

---

Section III. Hazards Identification
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
Acute Health Effects
eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria.
Chronic Health Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Tumorigenic effects.
Rat TDLo Oral 9950 mg/kg for 52 weeks intermittent
Toxic Effects:
Tumorigenic - Neoplastic by RTECS criteria
Skin and Appendages - Tumors
Rat TDLo Subcutaneous 5900 mg/kg for 43 weeks intermittent
Toxic Effects:
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - Tumors
Liver - Tumors
Mouse TDLo Oral 11 gm/kg for 47 weeks intermittent
Toxic Effects:
Tumorigenic - Equivocal tumorigenic agent by RTECS criteria
Lung, Thorax, or Respiration - Tumors
Blood - Tumors
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.

---

Section IV.First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention.
Skin ContactIn case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
InhalationIf the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
IngestionINDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive.
Continued on Next Page
3,3'-Dihydroxybenzidine

---

Section V.Fire and Explosion Data
Not available.
FlammabilityMay be combustible at high temperature.Auto-Ignition
Flammable LimitsNot available.
Flash PointsNot available.
Combustion ProductsThese products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2).
Fire Hazards
Not available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.

---

Section VI.Accidental Release Measures
Irritating material. Carcinogenic material.
Spill Cleanup
Use a shovel to put the material into a convenient waste disposal container. Consult federal, state, and/or local authorities for
Instructions
assistance on disposal.

---

Section VII. Handling and Storage
IRRITANT. CARCINOGEN. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container
Handling and Storage
and store in a dry, cool place. Avoid excessive heat and light. Do not breathe dust.
Information
Always store away from incompatible compounds such as oxidizing agents.

---

Section VIII. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
Engineering Controls
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Splash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
Personal Protection
specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure LimitsThis chemical is classified as a carcinogen. There is no acceptable exposure limit for a carcinogen.

---

Section IX. Physical and Chemical Properties
Solid. (Light yellow ~ reddish-yellow,Solubility
Physical state @ 20°CSoluble in DMF.
crystalline powder ~ powder.)
Very slightly soluble in water.
Not available.
Specific Gravity
Molecular Weight216.24Partition CoefficientNot available.
Boiling PointNot available.Not applicable.
Vapor Pressure
Melting Point292°C (557.6°F)Vapor DensityNot available.
Not available.Not available.
Refractive IndexVolatility
Critical TemperatureNot available.OdorNot available.
Not available.Not available.
ViscosityTaste

---

Section X.Stability and Reactivity Data
Stability

---

This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of InstabilityAvoid excessive heat and light.
IncompatibilitiesReactive with oxidizing agents.

---

Section XI. Toxicological Information
RTECS NumberDV4900000
Eye Contact. Ingestion. Inhalation.
Routes of Exposure
Not available.
Toxicity Data
Continued on Next Page
3,3'-Dihydroxybenzidine
Chronic Toxic EffectsCARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Tumorigenic effects.
Rat TDLo Oral 9950 mg/kg for 52 weeks intermittent
Toxic Effects:
Tumorigenic - Neoplastic by RTECS criteria
Skin and Appendages - Tumors
Rat TDLo Subcutaneous 5900 mg/kg for 43 weeks intermittent
Toxic Effects:
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - Tumors
Liver - Tumors
Mouse TDLo Oral 11 gm/kg for 47 weeks intermittent
Toxic Effects:
Tumorigenic - Equivocal tumorigenic agent by RTECS criteria
Lung, Thorax, or Respiration - Tumors
Blood - Tumors
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Acute Toxic EffectsIrritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye
is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

---

Section XII.Ecological Information
Not available.
Ecotoxicity
Environmental FateNot available.

---

Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.

---

Section XIV. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
PIN NumberNot applicable.
Proper Shipping NameNot applicable.
Packing Group (PG)Not applicable.
DOT Pictograms

---

Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS ClassificationCLASS D-2B: Material causing other toxic effects (TOXIC).
(Canada)
EINECS Number (EEC)Not available.
EEC Risk StatementsR36/37/38- Irritating to eyes, respiratory system and skin.
R45- May cause cancer.
3,3'-Dihydroxybenzidine
TCI laboratory chemicals are for research purposes only and are NOT intended for use as drugs, food additives, households, or pesticides. The information herein is believed to be correct, but does not claim
to be all inclusive and should be used only as a guide. Neither the above named supplier nor any of its subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information
contained herein. Final determination of suitability of any material is the sole responsibility of the user. All chemical reagents must be handled with the recognition that their chemical, physiological,
toxicological, and hazardous properties have not been fully investigated or determined. All chemical reagents should be handled only by individuals who are familiar with their potential hazards and who have
been fully trained in proper safety, laboratory, and chemical handling procedures. Although certain hazards are described herein, we can not guarantee that these are the only hazards which exist. Our MSDS
sheets are based only on data available at the time of shipping and are subject to change without notice as new information is obtained. Avoid long storage periods since the product is subject to degradation
with age and may become more dangerous or hazardous. It is the responsibility of the user to request updated MSDS sheets for products that are stored for extended periods. Disposal of unused product
must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment (e.g. protective
goggles, protective clothing, breathing equipment, facial mask, fume hood). For proper handling and disposal, always comply with federal, state, and local regulations.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

DATA ITEMS CITED :

8

MOLECULAR FORMULA :

C12-H12-N2-O2

MOLECULAR WEIGHT :

216.26

WISWESSER LINE NOTATION :

ZR BQ DR DZ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

9950 mg/kg/52W-I

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5900 mg/kg/43W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Multiple routes

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

6900 mg/kg/43W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

11 gm/kg/47W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5040 mg/kg/52W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1620 gm/kg/45W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :

TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

14 gm/kg/43W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - tumors Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :

Phage inhibition capacity

TEST SYSTEM :

Bacteria - Escherichia coli

DOSE/DURATION :

100 mmol/L

REFERENCE :

MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949- Volume(issue)/page/year: 31,11,1979