VP 14637

Modify Date: 2023-01-18 21:59:37

VP 14637 structure	Common Name	VP 14637
	CAS Number	235106-62-4	Molecular Weight	510.51
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₂N₁₀O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VP 14637

MDT-637 (VP 14637) is a novel respiratory syncytial virus (RSV) fusion inhibitor with an IC50 of 1.42 ng/mL.

Name	2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)
Synonym	More Synonyms

Description	MDT-637 (VP 14637) is a novel respiratory syncytial virus (RSV) fusion inhibitor with an IC50 of 1.42 ng/mL.
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> RSV
Target	IC50: 1.42 ng/mL (RSV)[1]
In Vitro	MDT‐637 has broad in vitro antiviral activity on clinical strains of different RSV genotypes and clades. MDT-637 inhibits three laboratory strains (RSV-A Long, RSV-A2, and RSV-9320) and four clinical strains (RSV-Memphis-37, RSV-LAP0824, and RSV-HAN1135) with IC50s range from 0.36 to 3.4 ng/mL[1].
Cell Assay	The laboratory and clinical isolates of RSV and various concentrations (ranging from 0.1 μM to 31.6 pM) of MDT‐637 (or ribavirin) are added to the HEp-2 cell monolayers at the same time. After 72 hours of incubation at 37°C, the cells and supernatants are harvested. An aliquot is immediately serially diluted and used for plaque assay[1].
References	[1]. Kim YI, et al. The antiviral effects of RSV fusion inhibitor, MDT-637, on clinical isolates, vs its achievable concentrations in the human respiratory tract and comparison to ribavirin. Influenza Other Respir Viruses. 2017 Nov;11(6):525-530.

Molecular Formula	C₂₅H₂₂N₁₀O₃
Molecular Weight	510.51

VP 14637

DC Chemicals Limited
China
Product Name: VP-14637
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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