235106-62-4
235106-62-4 structure
- Name: VP 14637
- Chemical Name: 2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)
- CAS Number: 235106-62-4
- Molecular Formula: C25H22N10O3
- Molecular Weight: 510.51
- Catalog: Signaling Pathways Anti-infection RSV
- Create Date: 2018-06-02 09:24:58
- Modify Date: 2023-01-18 21:59:37
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MDT-637 (VP 14637) is a novel respiratory syncytial virus (RSV) fusion inhibitor with an IC50 of 1.42 ng/mL.
| Name | 2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) |
|---|---|
| Synonyms | VP 14637 |
| Description | MDT-637 (VP 14637) is a novel respiratory syncytial virus (RSV) fusion inhibitor with an IC50 of 1.42 ng/mL. |
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| Related Catalog | |
| Target |
IC50: 1.42 ng/mL (RSV)[1] |
| In Vitro | MDT‐637 has broad in vitro antiviral activity on clinical strains of different RSV genotypes and clades. MDT-637 inhibits three laboratory strains (RSV-A Long, RSV-A2, and RSV-9320) and four clinical strains (RSV-Memphis-37, RSV-LAP0824, and RSV-HAN1135) with IC50s range from 0.36 to 3.4 ng/mL[1]. |
| Cell Assay | The laboratory and clinical isolates of RSV and various concentrations (ranging from 0.1 μM to 31.6 pM) of MDT‐637 (or ribavirin) are added to the HEp-2 cell monolayers at the same time. After 72 hours of incubation at 37°C, the cells and supernatants are harvested. An aliquot is immediately serially diluted and used for plaque assay[1]. |
| References |
| Molecular Formula | C25H22N10O3 |
|---|---|
| Molecular Weight | 510.51 |