dBRD9 dihydrochloride
Modify Date: 2024-04-09 23:01:01
dBRD9 dihydrochloride structure
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Common Name | dBRD9 dihydrochloride | ||
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| CAS Number | 2341840-98-8 | Molecular Weight | 856.755 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C40H47Cl2N7O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of dBRD9 dihydrochloridedBRD9 dihydrochloride is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide.dBRD9 does not degrade BRD4 or BRD7 at concentrations up to 5 uM.dBRD9 exhibits antiproliferative effects in human AML cell lines. |
| Name | dBRD9 dihydrochloride |
|---|
| Description | dBRD9 dihydrochloride is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide.dBRD9 does not degrade BRD4 or BRD7 at concentrations up to 5 uM.dBRD9 exhibits antiproliferative effects in human AML cell lines. |
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| References | 1. Remillard D, et al. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743. |
| Molecular Formula | C40H47Cl2N7O10 |
|---|---|
| Molecular Weight | 856.755 |
| InChIKey | OFXYLGKIVJYIAC-UHFFFAOYSA-N |
| SMILES | COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)CC(=O)NCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.Cl |