dBRD9 dihydrochloride

Names

[ Name ]:
dBRD9 dihydrochloride

Biological Activity

[Description]:

dBRD9 dihydrochloride is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide.dBRD9 does not degrade BRD4 or BRD7 at concentrations up to 5 uM.dBRD9 exhibits antiproliferative effects in human AML cell lines.

[References]

1. Remillard D, et al. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₄₇Cl₂N₇O₁₀

[ Molecular Weight ]:
856.755

Related Compounds

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