ABC99
Modify Date: 2025-08-25 18:53:27
ABC99 structure
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Common Name | ABC99 | ||
|---|---|---|---|---|
| CAS Number | 2331255-53-7 | Molecular Weight | 456.879 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 565.9±60.0 °C at 760 mmHg | |
| Molecular Formula | C22H21ClN4O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 296.1±32.9 °C | |
Use of ABC99ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM[1]. |
| Name | ABC99 |
|---|---|
| Synonym | More Synonyms |
| Description | ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 13 nM (Notum)[1] |
| In Vitro | ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner[1]. ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner[1]. Western Blot Analysis[1] Cell Line: SW620 cells Concentration: 0.1~10 μΜ Incubation Time: 2 hours Result: Inhibited NOTUM in a concentration-dependent manner. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 565.9±60.0 °C at 760 mmHg |
| Molecular Formula | C22H21ClN4O5 |
| Molecular Weight | 456.879 |
| Flash Point | 296.1±32.9 °C |
| Exact Mass | 456.120056 |
| LogP | 2.24 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.710 |
| 7-(4-Chlorobenzyl)-2-[(2,3-dihydro-4H-1,4-benzoxazin-4-ylcarbonyl)oxy]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione |
| ABC99 |
| Imidazo[1,5-a]pyrazine-1,3(2H,5H)-dione, 7-[(4-chlorophenyl)methyl]-2-[[(2,3-dihydro-4H-1,4-benzoxazin-4-yl)carbonyl]oxy]tetrahydro- |