2331255-53-7

2331255-53-7 structure

Name: ABC99
Chemical Name: ABC99
CAS Number: 2331255-53-7
Molecular Formula: C₂₂H₂₁ClN₄O₅
Molecular Weight: 456.879
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2021-08-11 07:02:04
Modify Date: 2025-08-25 18:53:27
ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM[1].

Name	ABC99
Synonyms	7-(4-Chlorobenzyl)-2-[(2,3-dihydro-4H-1,4-benzoxazin-4-ylcarbonyl)oxy]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione ABC99 Imidazo[1,5-a]pyrazine-1,3(2H,5H)-dione, 7-[(4-chlorophenyl)methyl]-2-[[(2,3-dihydro-4H-1,4-benzoxazin-4-yl)carbonyl]oxy]tetrahydro-

Description	ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt
Target	IC50: 13 nM (Notum)[1]
In Vitro	ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner[1]. ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner[1]. Western Blot Analysis[1] Cell Line: SW620 cells Concentration: 0.1~10 μΜ Incubation Time: 2 hours Result: Inhibited NOTUM in a concentration-dependent manner.
References	[1]. Suciu RM, et al. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling. ACS Med Chem Lett. 2018;9(6):563-568.