Bay 36-7620

Modify Date: 2024-01-07 17:43:58

Bay 36-7620 structure	Common Name	Bay 36-7620
	CAS Number	232605-26-4	Molecular Weight	278.35
	Density	N/A	Boiling Point	471.861ºC at 760 mmHg
	Molecular Formula	C₁₉H₁₈O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	199.799ºC

Use of Bay 36-7620

BAY 36-7620 is a potent and noncompetitive antagonist of mGlu1 Receptor (IC50=0.16 μM) with inverse agonist activity. BAY 36-7620 inhibits tumor growth and prolongs the survival of mice with tumors by inhibiting mGlu1 receptor. BAY 36-7620 suppresses AKT phosphorylation in A549 tumors. BAY 36-762 has neuroprotective effect in acute subdural hematoma rat model.BAY 36-7620 is used in non-small cell lung cancer and breast cancer research[1][2][3][4].

Name	(3aS,6aS)-5-methylidene-3a-(naphthalen-2-ylmethyl)-1,4,6,6a-tetrahydrocyclopenta[c]furan-3-one
Synonym	More Synonyms

Description	BAY 36-7620 is a potent and noncompetitive antagonist of mGlu1 Receptor (IC50=0.16 μM) with inverse agonist activity. BAY 36-7620 inhibits tumor growth and prolongs the survival of mice with tumors by inhibiting mGlu1 receptor. BAY 36-7620 suppresses AKT phosphorylation in A549 tumors. BAY 36-762 has neuroprotective effect in acute subdural hematoma rat model.BAY 36-7620 is used in non-small cell lung cancer and breast cancer research[1][2][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR 1:0.16 μM (IC50) mGluR1a:0.38 μM (IC50) mGluR2:0.14 μM (IC50) mGluR 5:0.24 μM (IC50)
References	[1]. Carroll FY, et al. BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol Pharmacol. 2001 May;59(5):965-73. [2]. Xia H, et al. Inhibition of metabotropic glutamate receptor 1 suppresses tumor growth and angiogenesis in experimental non-small cell lung cancer. Eur J Pharmacol. 2016 Jul 15;783:103-11. [3]. Dolfi SC, et al. Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. Oncotarget. 2017 Jul 4;8(27):44639-44653. [4]. De Vry J, et al. Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620. Eur J Pharmacol. 2001 Oct 5;428(2):203-14.

Boiling Point	471.861ºC at 760 mmHg
Molecular Formula	C₁₉H₁₈O₂
Molecular Weight	278.35
Flash Point	199.799ºC
Exact Mass	278.13100
PSA	26.30000
LogP	3.89170
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.633

hms3269k21

bay-36-7620

unii-0p934rsf8b

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: BAY 36-7620
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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