693790-96-4
693790-96-4 structure
- Name: BAY 73-1449
- Chemical Name: BAY 73-1449
- CAS Number: 693790-96-4
- Molecular Formula: C26H23N3O3
- Molecular Weight: 425.48
- Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
- Create Date: 2020-08-08 16:55:46
- Modify Date: 2024-01-10 15:28:54
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BAY 73-1449 is a selective antagonist of prostacyclin IP receptor, with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure[1].
| Name | BAY 73-1449 |
|---|
| Description | BAY 73-1449 is a selective antagonist of prostacyclin IP receptor, with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure[1]. |
|---|---|
| Related Catalog | |
| Target |
IP Receptor:<0.1 nM (IC50) |
| In Vivo | BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats[1]. BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats[1]. BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats[1]. Animal Model: Male Wistar rats (250-350 g) are ligated portal vein[1] Dosage: 0.1, 1 mg/kg Administration: A single i.v. Result: Significantly reduced shunt flow without affecting mesenteric flow. |
| References |
| Molecular Formula | C26H23N3O3 |
|---|---|
| Molecular Weight | 425.48 |