3-Deazauridine
Modify Date: 2025-08-27 20:37:36
3-Deazauridine structure
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Common Name | 3-Deazauridine | ||
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| CAS Number | 23205-42-7 | Molecular Weight | 243.21 | |
| Density | 1.718g/cm3 | Boiling Point | 528ºC at 760mmHg | |
| Molecular Formula | C10H13NO6 | Melting Point | 233-235ºC | |
| MSDS | N/A | Flash Point | 273.1ºC | |
Use of 3-Deazauridine3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1]. |
| Name | 3-Deazauridine |
|---|---|
| Synonym | More Synonyms |
| Description | 3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1]. |
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| Related Catalog | |
| Target |
Cytidine triphosphate synthase[1] |
| In Vitro | 3-Deazauridine (DAUR) 对 L1210 白血病细胞具有优异的抗肿瘤活性[1]。 |
| In Vivo | 3-Deazauridine (DAUR) (250 mg/kg/天；腹腔注射；1-9 天) 对小鼠中的 L1210 白血病细胞显示出中等活性[1]。 3-Deazauridine (腹腔注射；给药 5 次) 对比格犬和恒河猴的致死剂量分别为 250 mg/kg/day 和 417 mg/kg/day，最低毒性剂量为 62.5 mg/kg/day 和 104 mg/kg/day，无毒剂量分别为 31.25 mg/kg/day 和 52 mg/kg/day[1]。 |
| References |
| Density | 1.718g/cm3 |
|---|---|
| Boiling Point | 528ºC at 760mmHg |
| Melting Point | 233-235ºC |
| Molecular Formula | C10H13NO6 |
| Molecular Weight | 243.21 |
| Flash Point | 273.1ºC |
| Exact Mass | 243.07400 |
| PSA | 112.15000 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.706 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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| RTECS | UV1148000 |
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3-Deazauridine CAS#:23205-42-7 |
| Literature: Journal of Organic Chemistry, , vol. 72, # 1 p. 173 - 179 |
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3-Deazauridine CAS#:23205-42-7 |
| Literature: Journal of Organic Chemistry, , vol. 72, # 1 p. 173 - 179 |
|
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3-Deazauridine CAS#:23205-42-7 |
| Literature: Journal of Organic Chemistry, , vol. 72, # 1 p. 173 - 179 |
| Precursor 3 | |
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| DownStream 0 | |
| 3-deazauridine |
| EINECS 245-488-8 |
| MFCD00006522 |