LDN-192960 hydrochloride

Modify Date: 2024-01-10 02:09:08

LDN-192960 hydrochloride structure	Common Name	LDN-192960 hydrochloride
	CAS Number	2309172-48-1	Molecular Weight	401.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₂Cl₂N₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LDN-192960 hydrochloride

LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].

Name	LDN-192960 hydrochloride

Description	LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Signaling Pathways >> Cell Cycle/DNA Damage >> Haspin Kinase
Target	IC50: 10 nM (Haspin); 48 nM (DYRK2)[1]
In Vitro	LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC50<1 μM), including CLK1 (IC50=0.21 μM), DYRK1A (IC50= 0.10 μM), DYRK2 (IC50=2 nM), DYRK3 (IC50=19 nM) and PIM1 (IC50=0.72 μM)[1].
References	[1]. Cuny GD, et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3491-4.

Molecular Formula	C₁₈H₂₂Cl₂N₂O₂S
Molecular Weight	401.35

DC Chemicals Limited
China
Product Name: LDN-192960 hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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