JAK3 covalent inhibitor-1

Modify Date: 2024-01-03 21:26:55

JAK3 covalent inhibitor-1 structure	Common Name	JAK3 covalent inhibitor-1
	CAS Number	2300106-50-5	Molecular Weight	448.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₇FN₆O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JAK3 covalent inhibitor-1

JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs[1].

Name	JAK3 covalent inhibitor-1

Description	JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK3:11 nM (IC50)
References	[1]. Casimiro-Garcia A, et al. Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J Med Chem. 2018 Dec 13;61(23):10665-10699.

Molecular Formula	C₂₂H₁₇FN₆O₂S
Molecular Weight	448.47