T-518
Modify Date: 2025-10-01 11:45:43
T-518 structure
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Common Name | T-518 | ||
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| CAS Number | 2276680-91-0 | Molecular Weight | 495.358 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H16F7N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of T-518T-518 (T518) is a potent, highly selective, brain penetrant, oral HDAC6 inhibitor with IC50 of 36 nM.T-518 did not obviously inhibit human HDAC1, 4, or 7 at 10 uM, which belongs to Class I or Class IIa HDAC.T-518 showed brain penetration in an oral dose and blocked HDAC6-dependent tubulin deacetylation at Lys40 in mouse hippocampus.T-518 decreased RIPA-insoluble tau accumulation (3-month treatment, 1 and 3 mg/kg), restored impaired axonal transport and novel object recognition in the P301S tau Tg mouse (tauopathy model) by 2-week treatment with dose 1 and 3 mg/kg. |
| Name | T-518 |
|---|
| Description | T-518 (T518) is a potent, highly selective, brain penetrant, oral HDAC6 inhibitor with IC50 of 36 nM.T-518 did not obviously inhibit human HDAC1, 4, or 7 at 10 uM, which belongs to Class I or Class IIa HDAC.T-518 showed brain penetration in an oral dose and blocked HDAC6-dependent tubulin deacetylation at Lys40 in mouse hippocampus.T-518 decreased RIPA-insoluble tau accumulation (3-month treatment, 1 and 3 mg/kg), restored impaired axonal transport and novel object recognition in the P301S tau Tg mouse (tauopathy model) by 2-week treatment with dose 1 and 3 mg/kg. |
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| References | 1. Tomohiro Onishi, et al. Sci Rep. 2021 Jul 29;11(1):15423. |
| Molecular Formula | C19H16F7N5O3 |
|---|---|
| Molecular Weight | 495.358 |